1: J Infect Dis 2000 Apr;181(4):1421-7

Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure.

Somani J, Bhullar VB, Workowski KA, Farshy CE, Black CM.

Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30333, USA.

In vitro susceptibility testing and genotyping were done on urogenital isolates of Chlamydia trachomatis from 3 patients, 2 of whom showed evidence of clinical treatment failure with azithromycin and one of whom was the wife of a patient.

All 3 isolates demonstrated multidrug resistance to doxycycline, azithromycin, and ofloxacin at concentrations >4.0 microg/mL. Recurrent disease due to relapsing infection with the same resistant isolate was documented on the basis of identical genotypes of both organisms. This first report of clinically

significant multidrug-resistant C. trachomatis causing relapsing or persistent infection may portend an emerging problem to clinicians and public health officials.

PMID: 10762573 [PubMed - indexed for MEDLINE]

2: Can J Cardiol 1999 Apr;15 Suppl B:13B-15B

Infectious agents that play a role in atherosclerosis and vasculopathies. What are they? What do we do about them?

Vercellotti G.

University of Minnesota, Minneapolis, Minnesota, USA.

Much of the published data suggest a link between herpes infection and atherosclerosis, as well as herpes infection and restenosis. Mechanistically, herpesvirus has been shown to promote inflammation, thrombin generation and platelet binding, and infected cells have been shown to be resistant to

apoptosis. There is also good evidence of a link between Chlamydia pneumoniae infection and atherosclerosis. In preliminary studies, antichlamydial antibiotic intervention has been shown to reduce significantly the incidence of cardiac

events in patients with coronary artery disease and in myocardial infarction survivors.

PMID: 10350677 [PubMed - indexed for MEDLINE]

Вторая статья, что называется, льет воду на Вашу мельницу. И мне самому такие данные весьма интересны, кстати перешлите эти данные д-ру Гилярову. Интересно было бы знать мнение специалиста. Так как я сейчас не получаю уведомления о публикациях, сообщите если он откликнется в этой дискуссии.

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